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PP 1420 – A breakthrough in appetite suppression

6 Oct, 2010

Over 30 000 deaths a year are caused by obesity in England alone and yet the need for safe and effective anti-obesity therapies is largely unmet.

With funding from the Seeding Drug Discovery initiative in 2007, Professor Steve Bloom and his team have developed a novel, synthetic form of pancreatic polypeptide (PP) that can cause a significant reduction in food intake and body weight in mice, and the lead compound, PP1420, entered Phase I clinical trials in mid 2010. If successful, the proposed research may lead to a treatment within five to eight years.

2 Comments leave one →
  1. 10 Nov, 2010 12:43 am

    I think this is a fabulous research and development idea. A polypeptide that will suppress appetite will hopefully fill a void in the anti-obesity treatment marketplace that so far has remained unconquered.

    The available phrmacological agents at the moment leave a lot to be desired in terms of efficacy and side effects which means a yawning gap exists that this drug if it passes all the clinical trial stages will fill.

    Fingers crossed. We need something to complement obesity surgery which is arguably the most effective obesity treatment to date.

  2. 12 Nov, 2010 10:10 am

    I am always in two minds about this type of research. Yes, obesity is a huge problem. But the money invested in medical R&D that my help a few of the most obese patients could be directed to more practical solutions. Obesity is a social problem, not a medical condition. More money needs to be spent tackling the root cause of obesity, not putting out the fires afterwards. I personally believe that we need government intervention in the food and drinks industry to help wean the population off high energy junk food.

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