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Wellcome Image of the Month: Beta Blockers

17 Feb, 2012

There’s a lot to get your heart racing in February: Charles Dickens Day (Feb  7), Darwin Day (Feb 12), Valentine’s Day (Feb 14), Pancake Day (Feb 21), but perhaps most importantly, and shamelessly linking us to February’s Wellcome Image of the Month, is National Wear Red Day (Feb 24) organised by the British Heart Foundation.

Founded by a group of medical professionals in 1961, the British Heart Foundation have been funding research into the causes, diagnosis, treatment and prevention of heart disease, and National Wear Red Day is part of their Red for Heart campaign which is running throughout February as part of National Heart Month.

The image above is a false-coloured scanning electron micrograph of beta blocker crystals. Beta blockers are a group of drugs that block the action of adrenaline and noradrenaline (fight-or-flight chemicals) on β-adrenergic receptors found, amongst other locations, in the heart, kidneys and skeletal muscle. They widen blood vessels, slow down heart rate and reduce the force at which blood is pumped around the body, resulting in a drop in blood pressure. For this reason, beta blockers are routinely used as treatment for cardiac arrhythmias, hypertension, heart failure and many other cardiovascular diseases. They are also effective at reducing the symptoms of anxiety such as palpitations and fast heart rate.

One of the first clinically used beta blockers, propranolol, was synthesised by Sir James Black (Scottish doctor and pharmacologist) in 1958. It was one of the most significant contributions to pharmacology in the 20th century, revolutionising the medical management of angina (chest pain) at the time. Propranolol is still used today, but many more refined and selective beta blockers have been developed, including atenolol, crystals of which are pictured above. Atenolol is specific to β1-adrenergic receptors (located mostly in the heart and kidneys) and was introduced as a replacement for propranolol in the treatment of hypertension.

February is an exciting time, but look after your heart and stick to colourful microscopic images of beta blockers instead of the prescription kind. And don’t forget to support National Heart Month by wearing red on Friday February 24.

Ruth Milne, Wellcome Images

Further reading:

NHS information on beta blockers.

Wellcome Images is one of the world’s richest and most unusual collections, with themes ranging from medical and social history to contemporary healthcare and biomedical science. All our images are available in digital form so please click the link above if you would like to use the picture that features in this post, or to quickly find related ones. Many are free to use non-commercially under the terms of a Creative Commons licence and full details of the specific licence for each image are provided.

Image Credit: Annie Cavanagh, Wellcome Images
One Comment leave one →
  1. 17 Feb, 2012 3:46 pm

    Great information..thanks j.

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